Hi @Sister, & @kmakm, I started on Pristiq 5-6 years ago, initially 50mg, quickly increased to 100mg. I had just started thinking about reducing the dose when I was diagnosed, so stayed on the 100mg. It all seemed to catch up with me late last year when I was doing it tough again, so my GP increased me to 150mg, and that's where I've stayed, for the time being.
The other thing to be aware of is that Pristiq in particular will require a carefully supervised reduction in dose to come off it, as apparently you can get quite a nasty rebound amongst other things if reduced too quickly. All of which I guess means I'm stuck on the higher dose for a bit longer :open_mouth:
Take care