@Penny001, I found the paclitaxel much easier than the AC chemo. The fact that is was weekly, rather than every three weeks was a bit of a nuisance, but at least it was over quicker. I was given medication to take before the infusion and also some to take home with me to be taken after. I had no problems with these. I did start developing peripheral neuropathy in my hands and feet, which starts out as a sort of tingling and numbness. Much like when the local anaesthetic given by a dentist starts wearing off. However, I do have other significant medical issues aside from the cancer, so the symptoms I had might well have been worse due to these other factors. If this starts happening to you (and remember not everyone has problems), mention it to your team, and they will take the appropriate action. To be honest, the chemo infusions, both the AC and Paclitaxel, were not in themselves a huge problem for me. I have a port in my upper chest as my veins are shot from multiple blood tests over the past twenty years or so, due to being on blood thinners. This meant that there was no "Hunt the Vein" for me and my main problem was boredom. That's why I took my own tea bags, coffee, (hospital stuff is crappy), my kindle and my knitting.