I had my 97th Herceptin infusion last week - 1st was Aug. 2011. It irritates me (which is a change from my initial fury) when people suggest they know the reason for my breast cancer. I have learned to reply, 'Yes, I've thought about that sometimes and I've come to the conclusion that there are just too many variables'. Then I change the subject. In bitch or feral cat mode I have heard myself say, 'Yes, we can never be certain, maybe it was a mis-alignment of the planets or maybe making mud pies with the sheep-dip powder did it!' (I grew up in the wheatbelt of WA).