Don't beat yourself up if depression pops up out of the blue, it is the Tamoxifen. Mine isn't constant thank goodness as I can't take antidepressants to help. Yesterday after saying I was fine, in the afternoon an absolute internal rage hit me. Honestly i could have knifed someone and kicked dirt on their body I was that bad, yet nothing had happened to upset me like that. In the night I changed the other way and cried myself to sleep. This morning I am fine again. I just warn the family to leave me be when I get like that. It does pass. Just another funny quirk of Tamoxifen. <3