Conservative treatments, such as splinting, NSAIDs and steroid injection, may be less effective to treat AI-induced CTS or trigger finger, compared with idiopathic CTS or trigger finger. Among AIs, anastrozole and letrozole reversibly bind to aromatase enzyme, while exemestane irreversibly binds thereto. However, the triggering of our patient was not improved after treatment with anastrozole. At first, our patient received local corticosteroid injections in both thumbs; however, the symptoms aggravated in both thumbs and resulted in locking. Thus, surgery was performed. While corticosteroid injections may be effective in treating conventional trigger digits, our findings suggest that AI-associated trigger digit requires surgical treatment.