After a break, Letrozole, continued...

@sickgirl And this one! K xox

I hear you all about the fatigue issue.  I mentioned to my Onc a couple of days ago about the persistent tiredness. ( My second appointment I had with him) as the first one I was too tired to even drive there to see him I got 20 minutes down the road and turned around. Naughty I know but hubby was away at the time and couldn't drive me   
Having been on Letrozole now for 5 months have recently developed sore joints in my hands.  (so much for lifting the teapot for a nice cuppa in the morning )  luckily gets better as the hands warm up though out the day and I start moving.   I think that's about it isn't it, one foot in front of the other as long as we keep moving forward. 

@Brenda5 I was 56 when I first started chemo and I was still getting my regular cycle. Chemo stopped that and sent me into menopause so now, five months down the track after chemo, I am wondering whether my cycle will return. I hope not but was told it could take up to two years to return! My BC was hormone -ve so I am not on any of those dreadful hormone drugs. I am still on herceptin for another five months.

I am wondering was 2.5 mg just too high a dose for me? I am very drug sensitive and been off it for a month now but 3 yrs on from Menopause I am still getting mild flushes so it must take a while to get out of the system. I am 56 so there is no danger of periods returning.

I’m constantly tired too. Before BC I was known as an energiser bunny! Don’t like the word *hate, but, I hate taking Letrozole!!!!!!!

I'm not sure whether I'm dealing with post-chemo fatigue, accumulation of poor sleep, or if it's Letrozole.  I am tired all the time.  A day's work is all I can manage and if I have too much on the weekend, I suffer for it badly.  I've always had energy to burn so this is hard to deal with.  As is the constant aches and now, the soft tissue injuries that I seem to be getting.  I'm wondering about a break from it but have to admit that I'm a bit scared to go off it, even for a short while... 4 years and 4 months left (or possible 9 years and 4 months).

@tigerbeth It will be interesting, let us know. Have you changed your diet in any way?

Had my bloods done this morning to check the cholesterol so it will be interesting to see the outcome .

@kezmusc My oncologist told me that they did a study where patients took an AI for three months on, three months off and so on (she didn't specify the overall duration) and it made no difference. She said they don't recommend it though as it makes compliance too difficult.

I get nausea with Letrozole too. More intermittent and less frequent than you though. Unpleasant.

@kmakm,  you probably don't read about it because you're not supposed to do it.  So nobody will study it because they would have to tell people to take breaks on purpose and see what happens.  

The theories of how long it takes to get out of your system and how long it takes to build up to the effective level is debatable and depends on how you metabolize Tamoxifen (nobody ever mentioned this along the way) and turn it into endoxifen or whatever the heck it turns it into. 

That being said, what I do know for certain is that each time something has given a bit and come back a bit less severe.   There is no doubt that it is the breaks, if not it's a very large coincidence.  The only thing that does not come back less is the nausea.   Sux to live with a mild dose of what feels like morning sickness on and off every day. Ugghhh.