Alternatives to Zoladex and Tamoxifan? & Genetic Testing for Drug Metabolism
Hi all,
Who has had Genetic Testing for Drug Metabolism?
I have and it has been spot on with understanding why over the years I have had sooo many side effects with different drugs.
At this stage the testing is not covering every medication, but it is improving it's data base the more people do the test.
It has been helpful when I have had my lumpectomy, my anesthetist tailor made my drug regime and I had no horrible side effects from the sedation or pain killers.
I was also able to see that Tamoxifen is a no go for me. I was interested to see why, so I rang the genetic testing company to see why it came up as Red when I typed it in on my report. They told me that I may or may not have side effects, but I will not metabolise the drug to make the effective ingredient for it to work.
I have told my onlocolgist this, and she is insisting I try it.
I had severe side effects with Zoladex, the physical, while crappy, I could put up with. But the mental side effects were debilitating; Severe Depression, Anger, Irrationality etc, hence we did not start the aromatse inhibitors.
My oncologist used a tool on the web (I think this has be spoken about in another post) and said that if I stopped taking the Zoladex that my 10 year survial rate would decrease by 2.7%. I was willing to take those odds, and we both agreed to stop the Zoladex.
But my last visit, she wants me to start the Tamoxifen, because, some women do not have any troubles with it. :/
Again I do not want to, because 1. my genetic test and the company say that studies show that my genetic make up will not metabolize the drug to make the effective ingreadient; and 2. I do not want to add to the horrid mental side effects that I am experiencing ( A little less now that I am not on Zoledex) but still life disruptive.
Because of my Genetic make up, I can't take nearly all of the antidpressents used to treat the side effects either.
Im about ready to find another oncologist that will listen.
What other alternatives to Tamoxifen are there? Other than Zoladex and Aromatase Inhibitors?
Is anyone out there not taking anything at all?
Thankyou for letting me rant,
xo
Heres a link to the genetic testing I had done if anyone is interested.
https://www.mydna.life/medication/
Who has had Genetic Testing for Drug Metabolism?
I have and it has been spot on with understanding why over the years I have had sooo many side effects with different drugs.
At this stage the testing is not covering every medication, but it is improving it's data base the more people do the test.
It has been helpful when I have had my lumpectomy, my anesthetist tailor made my drug regime and I had no horrible side effects from the sedation or pain killers.
I was also able to see that Tamoxifen is a no go for me. I was interested to see why, so I rang the genetic testing company to see why it came up as Red when I typed it in on my report. They told me that I may or may not have side effects, but I will not metabolise the drug to make the effective ingredient for it to work.
I have told my onlocolgist this, and she is insisting I try it.
I had severe side effects with Zoladex, the physical, while crappy, I could put up with. But the mental side effects were debilitating; Severe Depression, Anger, Irrationality etc, hence we did not start the aromatse inhibitors.
My oncologist used a tool on the web (I think this has be spoken about in another post) and said that if I stopped taking the Zoladex that my 10 year survial rate would decrease by 2.7%. I was willing to take those odds, and we both agreed to stop the Zoladex.
But my last visit, she wants me to start the Tamoxifen, because, some women do not have any troubles with it. :/
Again I do not want to, because 1. my genetic test and the company say that studies show that my genetic make up will not metabolize the drug to make the effective ingreadient; and 2. I do not want to add to the horrid mental side effects that I am experiencing ( A little less now that I am not on Zoledex) but still life disruptive.
Because of my Genetic make up, I can't take nearly all of the antidpressents used to treat the side effects either.
Im about ready to find another oncologist that will listen.
What other alternatives to Tamoxifen are there? Other than Zoladex and Aromatase Inhibitors?
Is anyone out there not taking anything at all?
Thankyou for letting me rant,
xo
Heres a link to the genetic testing I had done if anyone is interested.
https://www.mydna.life/medication/
