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Shakalker's avatar
Shakalker
Member
6 years ago

Joint issues or rheumatoid arthritis?

After 5 months of Letrozole and now a 3 week holiday from it because of developing very sore trigger fingers in both hands that has now increased to thumbs and wrists with persistent bone aches, my GP ordered a blood test for Rheumatoid Factor the normal range is less than 14, mine is at 508.

I’m now waiting to see a rheumatologist to assess if it is actually rheumatoid arthritis 🙁

Has anyone else had their RF go up after Aromatase Inhibitors?
  • Hello I was diagnosed last year with ILC and I have been taking Letrozole for 3 months now. I have been getting a lot of pain in my feet legs ankles hands and wrist, feels like it’s in my bones and is getting worse. When it’s really bad I can’t go to work and I take endone to try and help with the pain. Has others gone through this as I am trying to put up with this as I would like to give it a good six months to see if it settles but I feel it’s getting worse.
  • @Shakalker - I came to BC from an arthritis background - and after being on Letrozole for 6 weeks, I had trigger finger as well that was extremely painful, with the base of my thumbs the worst pain ever.  I ended up on prednisone in Feb this year, just so I could play my ukulele at a uke festival we were playing at!  It made a HUGE difference.  It continued on Exemestane.  If you check out other Letrozole/AI posts, it is quite a common side effect on AIs specially for those without out previous arthritis symptom!  However, it is rarely mentioned by our Oncs to be one to 'look for'. 

    My mother had rheumatoid arthritis but I've been told I have osteo arthritis - and not sure if it has been checked specifically for RF.  I DO know that my CRP factor (which indicates inflammation) has been thru the roof for the last 10 years (way before my BC diagnosis) so much so that the GP rarely even mentions it now even tho it is way over the 'norm'. 

    I should ask for the RF to be tested too!! Usually with RF you have deformed fingers as well, I thought ..... the tips of 2 of my fingers are facing 'west' but they are not anything like my mother's hands.

    I am on oils now that are helping.
  • I have taken Letrozole for almost seven years - no arthritis and while improvement is at the speed of a glacier, my Taxol-related peripheral neuropathy continues to improve. 
  • Shakalker if you scroll through 'Tests, treatment and side effects' you will read of similar experiences. I have both rheumatoid arthritis and severe peripheral neuropathy in my feet. These coincide with taking Arimidex and x3 weekly Hercepton infusions (I am into my eighth year) and I  take medications for the arthritis with some benefit. The peripheral neuropathy persists.