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Electra's avatar
Electra
Member
7 years ago

Anti hormone therapy, Anastrozole, sexual function

I am 66 and was diagnosed with early breast cancer, estrogen positive, in June and have had breast conservation surgery and completed 16 treatments of radiation last week. On Monday I have to see my medical oncologist who will give me the yeah or nay to anti hormone therapy on Anastrozole for five years. The treatments seem to be getting more problematic as I advance through them. The surgery in hindsight seems like a breeze.

The literature on the side effects of Anastrozole are mind blowing; going through menopause (again), I am a lesbian so why I want a men-o-pause is beyond me (joke!), nausea, vomiting, elevated cholesterol, fluid retention, joint pains, dry vagina, bone loss, loss of sexual desire.

I have read of women who have had negative changes in the way they view their bodies and sexual functioning and desire but I am having a different experience. After the operation I became aware for the first time in my life how much I appreciate my breasts and I want them to be a part of my identity. When I first grew breasts, I saw them as a restriction to playing cricket with the neighbourhood kids. I never saw their power and beauty before now.

The other major change for me sexually is that the sex switch in my brain has been turned on again. I am single and am now contemplating and fantasising on sharing intimacy, loving and sex with another woman as a part of my future. A number of years ago I was going through a difficult patch and had shut down any thoughts of this to help cope getting through everyday life.

I would love to hear your thoughts on any of the above. What has been your experience on Anastrozole and the side effects. Thanks for reading my story and I thank you in advance for your input. Many of the discussions and responses on this site have helped me enormously with questions I have had over the past few months.


  • @SoldierCrab? (I'm having a mental block which is not unusual - I have got you right as an administrator, haven't I?)
  • Hi there @Electra ...welcome with your first post, although I gather you've been reading other posts for the past few months. I'm 60 and also post menopausal. (Was post menopausal in my mid thirties, so very early). I was diagnosed two years ago, six months chemo then bilateral mastectomy thereafter. Couldn't have rads due to preexisting autoimmune condition. Am now on leterozole, which is also an aromatase inhibitor, similar to anastrozole (Arimidex). Have been for about a year now. Some folks get all or many of the side effects listed on the information blurb, and some get very few. You really won't know until you start. For me, because I have three overlapping autoimmune diseases, with their attendant problems, as well as the cancer and other shit, it's hard for me to apportion blame for various symptoms. For example, my scleroderma gives me severe joint pain and stiffness as well as muscle and tendon pain due to stiffness of the connective tissues. So what additional joint problems are from the leterozole, and what from progression of the other? I already had osteoporosis prior to starting on the leterozole, probably from the very early menopause as well as having been on cortisone (panafcort) for years now, So the bone thinning thing is also blurred as to what is responsible for further loss. As far as Downunder and libido, well for me, to further use the automotive slant used by our own inimitable @onemargie  on the sex thread, sometimes I have to give the old chorrie (South Africanism for old car) a push start and then pop the clutch to get the motor turning over. The old Bachman Turner Overdrive song thing of Taking Care of Business comes to mind. A squirt of this and a rub of that works wonders for me when I feel the need. I say give it a go, you can always stop if you can't bear it, but you won't have the same options the other way if things go pear shaped.
  • Such positive words Sister. Top marks to your oncology centre for employing a sexual health consultant and all the best for your appointment with her. It does seem to be a common problem but is not addressed by the medical profession in cancer treatment. A week ago I requested to join the "Let's talk about vaginas" group but have not received a reply yet.
  • @electra Power to you, woman!  But it seems that many of us have struggled with sexuality after menopause (natural or forced) and AIs.  I've still to find out how Letrozole will affect me - natural menopause and chemo have had enough impact.  My oncology centre has just employed a sexual health consultant and I'm going to be seeing her on her first day!  I want to head off any further problems.  Have you joined the "Let's talk about vaginas" group?