goodbye xeloda hullo to navelbine
Hi to everyone, just thought I would drop by and say that after 34 months of xeloda its time for a change, I had scans last week and went back to my oncologist yesterday, he had been discussing with m...
Forum Discussion
The trial drug I am now on is a kinase inhibitor (CDK4 and 6) just like ribociclib and paclociclib. It is a newer generation of these drugs and has had promising results in metastatic breast cancer trials to date. Unfortunately, it causes diarrhoea in 80% of people, so the trial I am on is a diarrhoea trial (or as I say to my teenage kids a 'poo trial'. This is a small trial where some people take the dose with food and some without food to see if the dosing regime has an impact on whether people get diarrhoea or not. Ribociclib and paclociclip cause neutropenia in a large number of patients, and even though abemaciclib can cause neutropenia it doesn't occur in as many patients as the other two.
I had been on Xeloda for 14 months and was still in remission. However, my oncologist decided that even though Xeloda was still working, my hands and feet could do with a break! So she put me on this 'poo trial'. You get a smart Galaxy phone with a special program to record your daily bowel movements - what a treat!!
So far I have had a bit of diarrhoea (about 2 hours after I started taking the drug), but it hasn't been as bad as when on Xeloda. I don't know whether you had this problem with Xeloda, but I got the most crippling bowel pain before a bout of diarrhoea. With abemaciclib (or Verzenio), I don't seem to get the pain.
Also, although only 5 days in I am not as tired as I was on Xeloda. Let's see if it works though - staging scans scheduled for 5 weeks time! I think hair thinning is a side effect of abemaciclib as well!
Let us know how things go for you too and good luck.
XX
I had been on Xeloda for 14 months and was still in remission. However, my oncologist decided that even though Xeloda was still working, my hands and feet could do with a break! So she put me on this 'poo trial'. You get a smart Galaxy phone with a special program to record your daily bowel movements - what a treat!!
So far I have had a bit of diarrhoea (about 2 hours after I started taking the drug), but it hasn't been as bad as when on Xeloda. I don't know whether you had this problem with Xeloda, but I got the most crippling bowel pain before a bout of diarrhoea. With abemaciclib (or Verzenio), I don't seem to get the pain.
Also, although only 5 days in I am not as tired as I was on Xeloda. Let's see if it works though - staging scans scheduled for 5 weeks time! I think hair thinning is a side effect of abemaciclib as well!
Let us know how things go for you too and good luck.
XX