Hi @jo_c, this must be a very difficult position to be in. The choice was pretty much taken away from me as I had stage 2 grade 3 IDC cancer (although only 2cm) with 1 lymph node involved. My oncologist strongly recommend I have chemo, so I did. I may have thought more about it if it hadn't already spread, but my reasoning was if it had already spread to 1 lymph node it was possible it was elsewhere. My benefit was 7%. I'm towards the end of my chemo, and so far it hasn't been as bad as I though it would be (I was lucky and haven't suffered any sickness and nausea) but side effects vary from person to person, and I'll be very happy when this phase is over.