Hi @JuneXie...I was diagnosed in September 2016 with Stage 3, Grade 3, Triple Positive (so Her2, ER and PR +), multifocal and with at least 1 node involved. I was (and still am) a public patient, and when advised to do chemo first, to be honest I was quite sceptical of their explanations. I thought their surgery lists were very long and that they were fobbing me off by doing the chemo first to keep me occupied and in a 'holding pattern' until surgery could be done. My instincts were to chop them both off now...give me a weedwhacker and I'll do it myself... Well, as it happens, when I did have my bilateral mastectomy with axillary node clearance on the left (the known to be feral boob), and sentinel node on the right. The pathology report on all the removed tissue, breasts and nodes, showed a complete pathological response, with no live cancer cells found at all, only the (quote) empty tumour beds. I remain NED (No evidence of disease) almost 7 years on. I was 58 at the time. Good luck with your treatment, and remember, this is the first time you've had breast cancer, but to your medical team, this is their bread and butter. They've treated hundreds if not thousands and are very up to date in the ever changing treatment protocols for different types and stages of breast cancer.