Hullo there, most find the fatigue is cumulative, worst near and after the end. You should be able to work through it, maybe needing a bit of time off after the 20 dose mark - usually it's five per week for 5 weeks. But if you have bad burning it might be a problem. Can you get Mepitel? I had my radio treatment in a public hospital where they never even mentioned mepitel and only found out about it on this forum, too late. Burned like nobody's business! Talk to your breast care nurse. If you do find the fatigue building up try to get help with your non work stuff, be ready to lie down after work and especially try to manage your sleep. But it's quite doable usually and work will keep your mind busy. Let us know how you go. Best wishes and take care.