Grade 3 Oncotype Test Chemo decisions

Question

Hi all,I’m in the challenging time of making decisions about chemo and would love to hear experiences from others journey particularly with any similar cancer.&nbsp;I have had lumpectomy on left breast results showing- Stage 2A invasive carcinoma 25mm Grade 3, HR+ PR-HER2- with lymphovascular invasion but all 13 lymph nodes sampled as clear.&nbsp;I am 39yo and very active and healthy (apart from this)!I pooled my savings to get the oncotype DX ordered- I am now waiting for results. (Still can’t believe we have to pay $5000 for this).I understand the Grade 3 PR negative and lymphovascular invasion detected are likely risk factors that tip towards benefits of chemo. But I have been reading more about the effectiveness of hormone therapies like OS+AI and that perhaps I could avoid chemo.&nbsp;I will let you all know my score when it comes back- I hope it’s low but if it’s high I’m facing such hard decisions that any similar experiences may help!thank you&nbsp;

chan7 · Answer

Thanks so much for replying Katie,I hope you are well now as it sounds like you really have it your all!Im still waiting for Oncotype result due next week. However such an amazing thing happened yesterday. I went to discuss all the hormone therapies with my oncologist and we revisited my histopathology and in the last week the pathologists had reviewed the microscopic results and issued a supplement report that down graded the grade from 3 to 2!&nbsp;Im hopeful this is a good sign the oncotype will hopefully come back low in which case I will likely opt for radiation and hormone therapies and not chemo.&nbsp;It’s quite a rollercoaster of highs and lows so I am celebrating this new news!:)

katie46 · Answer

Hi Chan7​&nbsp;I was 50 when diagnosed. IDC stage 2 grade 3, 2cm, 1 lymph node positive, ER+ PR+ HER2 -. I had a lumpectomy, chemo, radiation and am now on letrozole, Goserelin injections monthly and abemaciclib for 2 years. I was diagnosed in October 2023.My oncologist strongly advised me to have chemo, mainly because of the high grade of cancer which put me at a higher risk of reoccurance. He told me even without the lymph node being positive he would still recommended chemo because of the high grade.I decided that I'd do whatever was recommended, throwing everything at it, and I'm comfortable with the decisions I made.&nbsp;It's an overwhelming time with lots of things happening. Ask to have another chat with your oncologist, and speak to your McGrath nurse if you have one, don't be afraid to ask lots of questions to help you make these decisions.&nbsp;All the best Katie&nbsp;