I had to take panadol osteo regularly after I finished taxol and continued herceptin and started letrozole. Everything ached, cramped when exercising and my ankles were unbearably stiff. I started on fish oil and managed to drop som weight and my joints improved a lot. Enough to stop regaular anything. I've gained some weight so sadly back on fish oil which has git me moving again. I didn't find anything changed after herceptin for me. But I do have less cramping issues now 2 years post chemo.