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Spillsy's avatar
Spillsy
Member
5 years ago

AI side- effects

Hi all, 
recently commenced and AI, and wondering if side- effects reduce over time. I was feeling pretty good, but since starting have had trouble sleeping, felt a bit down and stressed out and tired, achy hips and ankles and on an emotional roller coaster again, keep putting on weight... any advice or tips. 
Bloody Breast cancer is the gift that keeps giving. 
I also feel like I can’t multitask or remember stuff, it’s 1.5 years after treatment, for me, I think I feel pretty good, then have a set back.... 


50 Replies

  • Thanks @Dory65, so they are not immediate. Good luck with the biopsies, 🤞🤞 that it’s all good 🍀
  • Hi @FLClover,
    the Tamoxifen related symptoms started straight away. I now have endometrial hyperplasia and have to go under a general anesthetic for numerous biopsies, hoping nothing malignant is found. I'm waiting for the appointment date. On the new drugs, I thought it was an improvement initially, but then the aching joints and insomnia gradually became obvious after about two - three months.
  • I was on arimidex for about 5 months, but had problems with sleeping and painful joints. My oncologist changed me over to exemestane. Have been on that for 2 weeks and although joints sore, I am sleeping better. It’s so different for everyone, but if it gets too hard talk to your medical team about a change...all the best to you.
  • Hi @Spillsy,
    Your thoughts and symptoms sound like mine. I also want to know about long term use. Will the side effects continue, get worse or diminish over time? I'm a few months into Zoladex and Letrozole. The insomnia, hot flushes and aching joints seem to be getting worse.
  • I’m eight years in on Letrozole - I don’t have any of the most common symptoms, joint aches and pains and menopause type symptoms - flushes etc. Letrozole can thin bones so talk to your oncologist or GP about vitamin D or calcium supplements. It can also cause vaginal dryness - vaginal lubricants  will help, as can oestrogen cream (sounds counter intuitive I know but the amounts are tiny). Main thing is that if you have significant side effects, don’t suffer in silence. Short breaks, changes in brand, small things can help. Best wishes.
  • Ok, I’m not far behind. I don’t have much experience with it obviously, but so many ladies on this forum do, and I’m sure they’ll be able to help you (and me) 🙂 x
  • Hello, how recently did you start the AI, and which one was it? I started Letrozole 2 weeks ago, also on Zoladex injections, and only feel hot flushes and worsened memory. I’m wondering whether symptoms need longer to appear. Hoping not