Hi @salbrooks I have her2+ and ER/PR negative Mets in lymph nodes and bones. I was treated for this same primary cancer in 2018/19 and it appeared to disappear. It came back in 2022. I am now on Herceptin and Perjeta every three weeks and zometa (bone strengthening) every three months. I have a pet and ct scan every three months. My cancer is currently inactive in all but one lymph node due to this treatment. Our cancer is one of the few that has so many options with targeted therapy. Herceptin is tratzumab and perjeta is pertuzumab, same as what you are having. The doxetaxol is just for the short term to kill off what they can.