Hi@Ady - have been on Letrozole 4 months + and managing ok although have had a raft of side effects . Joint pain managed with Caltrate Bone Health which contains Magnesium as well as Calcium/ Vit D one in the morning and one afternoon as well as a Krill oil capsule daily per recommendation of medical oncologist.I also do a twice weekly gentle stretch and balance class as well as walk most days for an hour. I am already osteoporotic and have had a fracture so also have a 6 monthly Prolia injection which counters the further bone thinning of Letrozole.My biggest worry is the near trebling of my cholesterol and spoke to someone else yesterday who has had the same - I do not want to go back on statins and prefer a low dose aspirin daily as statins caused major problems with my mental functioning- I thought I was developing dementia but clearly was not as within 3 weeks of stopping statins I was back to normal. I have noticed a tendency to fatigue and depression which my daily walk helps a lot - probably by releasing endorphins .I am far from athletic but can’t tell you how much walking helps me amd some days it hurts but I seem to be able to walk thru discomfort and it goes away.Like everyone I find things tough at times both physically and emotionally but am continuing with Letrozole and taking each day at a time. I noted the dietary comments of @Deanne and offer the following I rarely eat red meat, am a tea drinker ,eat naked ginger often as well as curries ( turmeric is a component) , salty foods are not my thing - maybe my diet helps.I also gave up aerated drinks as I have been told they are not wise if you are osteoporotic. Maybe I have been lucky or maybe there is something I have gotten right dunno.