Inavolisib vs Alpelisib
Hello Thrivers I was diagnosed last September stage 4 de-nova. The cancer had spread from my breast to lymph nodes, to spine and right hip. Pr,er positive her2 negative. I started on Tamoxifin, then ...
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Hi @Cheryln38,
thanks for filling me in, that's really helpful. I hope you get something useful from your CaSP screening, that is what alerted my oncologist to my pik3ca gene, and probably is the reason the CDK4 treatment stopped working. I had a similar thing with that initial line of treatment, it reduced tumors in my lymph nodes and lining of my lungs considerably, but then new mets popped up in my liver and bones. I've had fulvestrant before and had no issues, just a bit of tenderness at the injection site. I had that administered by Nurse at Home, so I am hopeful that might again be an option as its a 4 hr round trip also for me to the trial hospital. Thats really tricky that your diagnosis has changed so much. Mine also changed from my very first diagnosis with early BC but that was more than 20 yrs ago, went from slightly pr+ to er+ when I had a recurrence in 2020. Mine has been quite a sneaky operator, travelling from the right breast somehow to the left lymph nodes ... & nobody had any real answers how that could have happened. Its all academic at this point though and while I haven't hit the treatment jackpot yet I'm doing pretty well and feeling hopeful for a bit longer. Good luck with everything & hope your side effects with the new drugs settle down.
and @ter1969 - I'm sorry to hear that Piqray wasn't for you and I hope that the Keytruda combo is the ticket. Good luck and keep us posted.
thanks for filling me in, that's really helpful. I hope you get something useful from your CaSP screening, that is what alerted my oncologist to my pik3ca gene, and probably is the reason the CDK4 treatment stopped working. I had a similar thing with that initial line of treatment, it reduced tumors in my lymph nodes and lining of my lungs considerably, but then new mets popped up in my liver and bones. I've had fulvestrant before and had no issues, just a bit of tenderness at the injection site. I had that administered by Nurse at Home, so I am hopeful that might again be an option as its a 4 hr round trip also for me to the trial hospital. Thats really tricky that your diagnosis has changed so much. Mine also changed from my very first diagnosis with early BC but that was more than 20 yrs ago, went from slightly pr+ to er+ when I had a recurrence in 2020. Mine has been quite a sneaky operator, travelling from the right breast somehow to the left lymph nodes ... & nobody had any real answers how that could have happened. Its all academic at this point though and while I haven't hit the treatment jackpot yet I'm doing pretty well and feeling hopeful for a bit longer. Good luck with everything & hope your side effects with the new drugs settle down.
and @ter1969 - I'm sorry to hear that Piqray wasn't for you and I hope that the Keytruda combo is the ticket. Good luck and keep us posted.