Bad pains in legs

Hi @Not_good_63_57, Your pain sounds very different to mine. First time it was pain from my lower back down my leg constantly which is classic nerve pain. This time, the physio says that it is muscles sending warning pain to protect my pelvis (b/c of mets). It is constant and severe. I would think if yours is related to meds it would be the letrozole rather than the denosumab. I have been on denosumab for 6 years (monthly) and was on letrozole for only 6 months. The side effects of all of these medications is very annoying. I am just waiting to get on a clinical trail using ipatasertib. Have to have my old tumours (that were frozen away) sequenced for about 500 genes before I can start. It should take 3 to 4 weeks. I also hate the waiting. Cheers Lisa