Hi @TaniaB. I was on Zoladex for 5yrs after developing a new tumour because I developed a resistance to tamoxifen in 2009.( My first BC was in 2005.) I had menopause symptoms - hot flushes, sleep issues etc. They were manageable if not annoying. They did get me down sometimes but I accepted if that's what I had to put up with to save my life, I would live with it. Side effects were about the same as tamoxifen I think. Some days worse than others. After my 5yrs on Zoladex finished, I couldn't bare the thought of my ovaries starting up again so I had a full hysterectomy including ovaries, in 2016, aged 49. I can't say I have noticed any difference between Zoladex and ovary removal, although because I progressed from one to the other it was probably just a continuation of menopausal symptoms. The one thing my Onc did tell me in 2009 was to try Zoladex to see what the menopausal stuff was like and I could choose ovary removal later. However if I had ovary removal straight up and the menopausal side-effects were really difficult, there was no going back. Maybe that could be a solution for you. It doesn't have to be either/ or, but see what going into menopause is like for you via Zoladex, and then you can choose the ovary option if you want.
I have had depression that pre-dates my BC in 2005 and I have struggled with that a lot. But whether it was the Zoladex or the whole shitty circumstances of BC that exacerbated it - or both - I couldn't say. But I would say to be watchful of mood issues. Whether it is the Zoladex or the stress of BC doesn't really matter - you may need support and understanding to guide you through. Whether that is friends or a counsellor/professional support, seek and accept whatever help you need to make the road easier.
I don't have any experience with Ai so I can't provide any advice there. There are no right answers, just what's right for you. I wish you well with your surgery and decision. Take good care of yourself.
