Oh dear, @Afraser, please forgive me, I didn't mean to imply you are an old crone. Sorry, sorry. Actually you are a real inspiration, you seem to have come through everything so well. And yes, everyone is different and responds differently. I guess I am still early on in this process and am constantly surprised that there isn't more definitively known about why these differences exist, and what will happen in any particular case. People say over and again that you have to make your own decisions and trust your own instincts but how do you know what to base those decisions on? When speaking to my onco for the first time he mentioned side effects from AI therapy but implied these were rare and other than bone loss would not have any great impact on my health or everyday life. He spoke about it as a simple drug with great results. As he is a highly recognised researcher and well-known in the field, I of course took this at face value. Only after I started reading story after story on blog after blog and forum after forum about the ghastly condition so many women were in did I ask more questions about it. I feel I understand it now (hence the long rave above, for which I apologise) but I still want to know why some women sail through it and others are virtually crippled. In my case, because my cancer was already so advanced and so close to potential mets, it is clear that if I don't take AI therapy I will be in major trouble. This has thrown me into a state of obsession again and I can't stop thinking about it, even though I desperately want something else in my life. Sorry if I overstate things sometimes but I guess I just can't believe half of what I am finding out!