Side effects are so variable, anyone starting letrozole or tamoxifen wouldn’t know what to think. The best advice can only be to try it and see how you go over a reasonable period of time. I do have bone thinning and vaginal dryness on letrozole but no aches, pains, flushes, hair thinning or increased cholesterol. I do
have lymphoedema (not related to
letrozole!) and the soft skin on my affected arm is often remarked on as a sign of my vigilance in moisturising, as dry and hardened skin can be a problem. But to be honest, I moisturise very irregularly, no skin dryness. All we do know is that the medication may make a difference about remaining cancer free and so we individually have to decide when the side effects outweigh those potential benefits.
