Forum Discussion

JMC's avatar
JMC
Member
21 days ago

Letrozole and dermatitis?

Hi all - I have been on letrozole for about 10 weeks now, following a lumpectomy and radiation for hormone positive ILC. Over the last couple of weeks I have developed a terribly itchy red rash over my legs and arms.  My GP is investigating the cause, but I wondered if anyone else had experienced this as a possible side-effect of letrozole?  I have seen other posts about rashes being a side effect of other AIs but not so much letrozole?  thanks!

4 Replies

  • Sorry to hear of the allergic reaction from Letrozole JMC​  (Letrozole is a generic form of the original medication and is made by many manufacturers under different names.)

    A rash is one of the possible side effects, sadly.  Here is ONE confirmed case & how it was treated (maybe send the link to your GP?):

    https://pmc.ncbi.nlm.nih.gov/articles/PMC4129361/ 

    Letrozole is available under its original brand name Femara as well as many generic manufacturer labels and brands, but may cost more. 

    Common Generic Brands and Suppliers:

    ARX-Letrozole

    Femolet

    Gynotril

    Letrozole GH / Letrozole generichealth

    Letrozole Sandoz

    Pharmacor Letrozole

    APO-Letrozole (Apotex)

    Letrozole AN

    Letrozole Actavis

    Teva Pharms - are all generic formulations of Femara


    Sometimes it can actually be the COATING on the tablet that may cause a problem. 
    The actual medical ingredients are the same as the 'original' brands (Femara, made by Novartis, is the original medicine with Letrozole as the active ingredient)... but the coating (designed to break down after a specific time in the stomach) 'may' be made of different ingredients to the 'parent' medicine.

    I hope the cortisone cream works for you to control it xx


  • I had the same reaction to Letrozole. I got changed to Anastrozole and found the rash slowly disappeared over time. 

  • Thanks so much - it is awful and the itch is driving me mad!  I do have some new cortisone cream today though which is helping.  Thanks again for jumping in to sympathise!

  • Hello
    I don’t have experience with this but wanted to comment so you know some one is reading.

    dermatitis is awful at the best of times. I hope you get some relief soon.