Trial Drug
Hi All, So was with oncologist on Monday and was offered to go on a free trial for a new drug. Just wondered if anyone knew anything about it. It is called Neratinib. Apparently it has been released ...
Forum Discussion
5% as opposed to what? No treatment? First, second or third line hormone treatment?
I've done precisely what we are told not to, and googled it. It's been refused approval in Europe. Pfizer developed the drug;, it's been sold twice after the Pfizer supported ExteNET trial stumbled to a halt in the US. They stopped recruiting at 2842 patients out of a planned 3800 and shortened the trial fron 3 yesrs to 2.
The side effects are extremely nasty--40% of the trial recipients reported severe diarrhoea and 21% discontinued the trial because of it.
The effectiveness, as far as I can see, is as low as 1.4% reduction in distant metastasis compared to the placebo.
I can't see where the 5% figure comes from, but maybe the researchers have a different set of data from the ExteNET results, Ask to see it.
I'd also be asking questions about who's funding the trial, a lot of money has been spent on the drug and it sounds like a dud. It's hugely expensive ( @$10000 US per month), the fact you might get it for free wouldn't convince me to take it having read the publically available data. More information required. Marg
I've done precisely what we are told not to, and googled it. It's been refused approval in Europe. Pfizer developed the drug;, it's been sold twice after the Pfizer supported ExteNET trial stumbled to a halt in the US. They stopped recruiting at 2842 patients out of a planned 3800 and shortened the trial fron 3 yesrs to 2.
The side effects are extremely nasty--40% of the trial recipients reported severe diarrhoea and 21% discontinued the trial because of it.
The effectiveness, as far as I can see, is as low as 1.4% reduction in distant metastasis compared to the placebo.
I can't see where the 5% figure comes from, but maybe the researchers have a different set of data from the ExteNET results, Ask to see it.
I'd also be asking questions about who's funding the trial, a lot of money has been spent on the drug and it sounds like a dud. It's hugely expensive ( @$10000 US per month), the fact you might get it for free wouldn't convince me to take it having read the publically available data. More information required. Marg