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Eastmum's avatar
Eastmum
Member
6 years ago

Bisphosphonates to reduce bone mets

I’d like to share something that I’ve learned from my oncologist. 
Bisphosphonates are used to reduce bone density loss in people who are being treated with AI for estrogen receptive breast cancer. One type of Bisphosphonate is zoledronic acid and is sold among other brand names as ‘aclasta’ and given as an injection. 
My bone density scan came back with amazing results - not a sign of osteoporosis at all, not even osteoperitic - however, my oncologist has been following the research that shows that giving zoledronic acid as part of adjuvant breast cancer treatment before there’s any indication of bone density loss, can reduce the chance of recurrence of the cancer as bone mets, particularly in post menopausal women. So off I go to get an aclasta injection. 
The most volatile side effect (though incredibly rare) is something called osteo necrosis of the jaw, so I had to get the all-clear from my dentist first. 
Here’s some research. Worth asking your oncologist if you feel you fit into the category that might benefit. 
https://www.cancer.gov/types/breast/research/adjuvant-bisphosphonates-meta-analysis
  • @Eastmum and @Primek yes this sounds exactly the same as Prolia. Ive been on these 6 monthly for 4 years. I was osteopenic at the end of chemo. I am no longer and have great bone health. It is renowned for its protection against a recurrence used in conjunction with an AI. There is yes a rare side effect that can happen to the jaw. 

    Ive not heard of Aclasta? Unless thats another name for Prolia. Ive shared in the past few years how good it is 😁

  • @melclarity is on prolia (at her expense) for this very reason and to improve her bone density also.
  • Hi @Eastmum, I finished chemo in Feb 2017 & have been on Letrozole since. I have mild osteopenia. At my last oncology review in August she suggested Zometa infusions every six months which is a biophosphonate. She mentioned it reduces risk of bone Mets. So I took it on that alone. I had flu like symptoms for 36 hours a day later but it was manageable. I had a check up too at the dentist before.