Hi @Rona, sorry to hear that you've had to change to the weekly infusions and prelong your treatment, but hopefully it will be kinder on your body. I have 8 more to go, and so far the side effects have been minimal and I'm generally feeling much better, although I know this might change the more infusions I get. My nails are my biggest concern at the moment, I'm hoping they don't get any worse than feeling a bit sensitive and a few of them turning brown. So far no tingling or numbness. The weekly blood tests and infusions are making me feel a bit like a pin cushion, but I don't want a port. I started working 2 days a week and it is great to be doing something normal. Hopefully you might get some taste back on the lower dose.