Hi @chipo, I can relate to how you are feeling, there is a lot to take in at the beginning. Getting a porta cath was the best thing I did as I have silly veins and thankfully have had no problems so far with it. The first access a few days after it was inserted was a bit sore but otherwise it is a small sting and I haven't used any numbing creams with it. I was lucky with my 4 rounds of AC to only have nausea and some fatigue but still worked part-time and kept up with my four year old. I am 5/12 way through paclitaxol and nausea gone, some days more tired than others but generally pretty good. I found walking every morning helps with the fatigue and taking one step at a time. Take care and hope your first chemo goes well x