Hi Anna15, Sorry it has taken a little bit to get back to you..(life!)To answer your question regarding BRCA 2, Being positive greatly increases the cancer of returning…it did! I ended up with having both breasts removed (no reconstruction) and also having the ovaries and fallopian tubes removed as these also are sites for breast cancer (or tumours)to develop due to being estrogon sensitive. They are not considered metastatic sites but are considered higher risk for breast cancer tumours. If it metastasises, likely areas appear to be spine, lungs but can really be anywhere.. be your own best advocate for your health! Knowing I had BRCA 2, made me more proactive in getting lumps and bumps seen to despite sometimes being told “it doesn’t feel cancerous”…I am no longer willing to wait to “see what happens” ….hope this answers your questions and if you have any more, just ask!