@ddon, the only study on cold therapy I can source is Japanese, listed in the post. It strongly shows that cold therapy does minimise the effects of Peripheral Neuropathy in Paclitaxel regimes. Patients used cold therapy on one side and not the other and the differences were notable. There seems a lot of ignorance around cold therapy and I am currently writing to my hospital, with the support of Oncologist, Breast Surgeon, Radiation Oncologist and Chemo Nurse Educator to promote its use in our Day Therapy unit.