The weekly regime is quite grueling. I initially felt pretty okay but by about the 5th week I started getting really tired and by the end was exhausted. I thought I would be able to work but wasn't able to. I was able to do some light exercise a few days per week up until week 10. I suffered quite a bit of shortness of breath, fluid retention and gastritis. I felt okay probably 1 to 2 days per week then it started again. But everyone is different and you won't know until you are on it. The effects are accumulative due to being weekly ...as apposed to the big dose and 3 week break. I ended up with some neuropathy and balance issues about 3/4 through and depression was also added in due to the whole no break thing. A few weeks on and I am doing much better on just herceptin except for fatigue continuing and reduced cardiac output...so I get to have a few weeks break now whilst that recovers. Hope it goes well...it is doable though. Kath x