Currently on 4x 3weekly AC - so far the first 10 days or so prettyhard. Not nausea so much as just TIRED and feeling flu-like.... Having a couple naps a day, about day 5-6 I really crashed. Have two young boys (3&5) at home, and another on the way. Having some to help (just watch them and run them about) is an immense help. I'm still managing cooking, light house chores but not much more.
Online grocery shopping and plenty of rest. How much care does he need? Many appts etc? I would count on at least a few days where you will need help at least.
But as Chriss says, everyone is different. My first round was not so bad but my second knocked me for a six, dreading the third....