I wouldn't say they get any worse. Some side effects you had for round one you won't have again like with me, all my facial sun spots came away and I had a whole scabby face for a few weeks. Other new side effects might crop up like for me rounds two and three really bad reflux but on dose 4 I didn't have it at all thank goodness. New side effect after round four was any hair I had left fell out and my nail beds on hands and toes lifted my nails for a week or two. Cutting them really short to stop leverage will preserve them and once the side effect settles down the nail beds will regrow under the nails.