@Pammy46 unfortunately Zoffiel is correct, in fact I posted new data from the Breast Cancer Foundation about Tamoxifen that in 1/3 of cases it doesnt work and the sneaky cancer cells are growing inspite of it. I had a recurrence in 2015 after 4yrs and being on Tamoxifen and Chemo threw me into menopause which was really difficult to deal with. I still get hot flushes and I believe that coupled with chemo is the culprit for weight gain which does not come off!!! GRRR!!! I am now on Arimidex which the Oncologist prefers over Tamoxifen, but Ive never been told to have my ovaries removed. I am however having a single mastectomy/reconstruction in 1.5 weeks. Id say you'll manage the side effects ok, and that it would be similar to what I went through which I know was unnatural and harsher. Hugs Melinda xo