Hi - I just saw your post and thought I would share with you. I had a 12 week course of Paclitaxel which I believe is similar (though not exactly the same) as TC along with immunotherapy. I am now having a course of Doxirubicin. I did get peripheral neuropathy in my hands and feet to the extent that I had to stop driving for a little while. This has improved since I stopped the Paclitaxel regimen but is still there a little bit in my feet - sometimes flaring a little more (I am able to drive again now). I didn't use the ice gloves or booties for much the same reason I never wore an ice cap - I just couldn't deal with the freezing situation on top of everything else. Your oncologist may be able to allay your fears a little if you speak with them. All the best with your treatment