Hi Sun, yes fatigue & joint pain are with us often. I've had a few adverse reactions to meds over the years, necessitating a long break. And it's during these break periods that I've felt the most well. I have metastasis scattered thoughout my skeleton - but my pelvis & sacrum area causing the most pain as it affects sitting/walking/lying. Trying to keep active with walking (I've an energetic dog) yoga/massage/singing, (good for the immune system) acupuncture & some meditation. And I'm about to explore Infrared saunas as I've read they combat pain & inflammation. Send another post sometime...go well. Elise.