ErSo - Trials on Mice have eradicated Metastatic Breast Cancer Cells - we need HUMAN trials now ...
Beating breast cancer Estrogen receptor–positive breast cancer is the most common type of breast cancer and, in its metastatic form, is currently incurable. In a new study, Boudreau et al. describe a compound, ErSO, that can activate the unfolded protein response, resulting in necrosis of human breast cancer cell lines in vitro. In vivo, this treatment induced complete regression of cell line and patient-derived orthotopic and metastatic breast cancer xenografts in mice. The authors showed that this treatment was well tolerated in mice, rats, and dogs and could provide a new avenue of intervention for this deadly disease. Abstract Metastatic estrogen receptor α (ERα)–positive breast cancer is presently incurable. Seeking to target these drug-resistant cancers, we report the discovery of a compound, called ErSO, that activates the anticipatory unfolded protein response (a-UPR) and induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. We then tested ErSO in vivo in several preclinical orthotopic and metastasis mouse models carrying different xenografts of human breast cancer lines or patient-derived breast tumors. In multiple orthotopic models, ErSO treatment given either orally or intraperitoneally for 14 to 21 days induced tumor regression without recurrence. In a cell line tail vein metastasis model, ErSO was also effective at inducing regression of most lung, bone, and liver metastases. ErSO treatment induced almost complete regression of brain metastases in mice carrying intracranial human breast cancer cell line xenografts. Tumors that did not undergo complete regression and regrew remained sensitive to retreatment with ErSO. ErSO was well tolerated in mice, rats, and dogs at doses above those needed for therapeutic responses and had little or no effect on normal ERα-expressing murine tissues. ErSO mediated its anticancer effects through activation of the a-UPR, suggesting that activation of a tumor protective pathway could induce tumor regression. https://news.illinois.edu/view/6367/339688859?fbclid=IwAR0h1IknctZG6-YwnsbeAm-4Q_Yi9piOYfUPc7z1ymYl-NIeZXH5W16zjUE#image-2 One lady actually wrote to one of the reseachers and he said to contact Bayer directly, as they bought the "rights" and as yet, they haven't scheduled clinical trials. I am sure that if controlling oestrogen was a major part of controlling Prostate or Testicular Cancer, they'd be RACING to get this to market ..... WE ALL NEED TO WRITE TO BAYER! Copy & Send this post to your Onc too!! Here is a Bayer contact the researcher gave: rose.talarico@bayer.com Hopefully, if LOTS OF PEOPLE from all around the world WRITE to Bayer - they may 'run with it' .... but the facts are, if something like this isn't profitable enough to them - it might get shelved! :(
Ask the Expert: Managing side effects of hormone blocking treatment with Dr Michelle White
Hello everyone! We will be hosting our next Ask the Expert Digital Event on Managing side effects of hormone blocking treatment with Dr Michelle White. Click here to register for the event. Approximately two thirds of all breast cancers are a type called hormone receptor positive. This means they use the hormones oestrogen and/or progesterone to grow. The recommended treatment for people with hormone receptor positive early breast cancer usually includes hormone-blocking therapy, a tablet taken daily for between five and 10 years. For people with metastatic breast cancer, hormone-blocking treatments can provide long term disease control. The side effects of these treatments may be mild and easily managed, but for some people they can significantly impact their quality of life. At this Ask the Expert event, we will hear from medical oncologist Dr Michelle White and BCNA Consumer Representative Kym Berchtenbreiter. Michelle specialises in treating women diagnosed with breast cancer and is the lead investigator for several local research studies and the development and conduct of clinical trials. Kym was diagnosed with early breast cancer in 2009 and will discuss the side effects she experienced from hormone-blocking treatment, her strategies to manage them and her advice for others. This session will address what you need to know about hormone-blocking treatment, including common side effects and how you can manage them, and how to ensure a good balance between quality of life, risk of recurrence and control of disease progression. During this event you will be able to ask Michelle and Kym questions. Please share your questions prior to the event via the question box on the registration page or email events@bcna.org.au. During the event you can submit questions via the discussion box on your screen. If you have any other questions prior to the event, please email events@bcna.org.au. For any technical difficulties on the evening, please contact Redback Studios on 1800 733 416. Event Details Date: Wednesday 29 June 2022 Time: 6.30pm - 7.45pm AEST Where: Online – from your computer, tablet or laptop Your Local Time: WA: 4.30pm NT, SA: 6.00pm QLD, ACT, NSW, TAS, VIC: 6.30pmMedicinal Cannabis Oil & reduction of pain, improvement in well being
Hi guys I've also put this link in the 'Early Days of Letrozole' thread - as so many are having extremely painful side effects and watching this video (shown last Dec) that follows the life & death of Dan Hallam (a young Aussie with Bowel Cancer) may help ..... The use of Cannabis Oil as a pain killer can make the difference in quality of life in MANY cancer sufferers (and other nasty conditions which can otherwise be debilitating to the extreme) ...... as this video shows as it follows the story of many (particularly kids.) Please watch the entire video before commenting ...... it takes a while, but it is well worth the watch, as it is Australian made & relates to our own health system. Share the link with family & friends. We NEED this to be freely available to those in chronic pain - especially those with Mets BC or extreme pain side effects from AIs https://www.youtube.com/watch?v=cmEjlMdLi5w
Subsidy for Verzenio (abemaciclib) expanded on the PBS
Hi everyone, I thought some of you may be interested to read about the recent expansion of the Pharmaceutical Benefits Scheme (PBS) listing of Verzenio (abemaciclib) to include its use in combination with Faslodex (fulvestrant). You can read the full details on the BCNA website link below: https://www.bcna.org.au/news/2021/10/subsidy-for-verzenio-abemaciclib-expanded-on-the-pbs/ We recommend talking to your treatment team if you have any questions about abemaciclib or fulvestrant. (This has also been posted in private group 'Living with metastatic breast cancer')Clinical Trials Update
Hello members, Our BCNA Senior Policy Officer has provided the below information regarding clinical trials that may be of interest to our members. These are also being shared in our Health Professionals Network News and the Metastatic Advisory Group (I shall post in the mets private group re EMBRACE Phase II trial). Nivolumab neoadjuvant/adjuvant clinical trial The CA209-7FL neoadjuvant/adjuvant breast cancer trial continues to be open to recruitment, running in South Australia, New South Wales and Victoria for patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative early-stage breast cancer. Bristol Myers Squibb will be implementing a digital advertising campaign expected to launch in October/November 2021. This will target both health professionals and patients. More information on the trial can be found here. EMBRACE Phase II Olaparib clinical trial EMBRACE is a Phase II clinical trial of the PARP inhibitor, Olaparib, in HR-deficient metastatic breast and relapsed ovarian cancer in patients without germline mutations in BRCA1 and BRCA2. Patients with metastatic triple negative breast cancer (TNBC) or relapsed platinum-sensitive high grade serous ovarian cancer (HGSOC) after first line/adjuvant therapy who have an eligible tumour molecular analysis result are suitable for the trial. There are 11 sites open in Australia in NSW, QLD, VIC, SA and WA. More information on the trial can be found here or by emailing embrace.study@sydney.edu.au We encourage members to talk with their treatment team in the first instance about any clinical trials.
2016 -2021 The Journey continues
Hi, It has been 4 years and 8 months since this journey of Breast Cancer started. I have been reading back over this chat and wow how that time changed my life and everything around cancer. So on July 28th, I went to Auburn Hospital for my operation under Dr ***. 4 hours into the operation she was notified that I had 44% cancer cells in my Sentinal Node so other nodes were advised to be removed. 23 nodes later,,, gone. This then brought my operation up to 6 hours. Recovery went fairly well. I was able to go back to work 2 weeks post op and did light duties and haven't stopped. Unfortunately, at pre-op there was no indication that I had an aggressive form of cancer so I had to undergo chemo, which was not discussed previously, only Radiotherapy treatment for 6 weeks. So fast forward to September 16 and I am going in for a Port a Cath insertion at Prince of Wales as there was nowhere doing them at the time I needed to start chemo. I had the first 3 lots of aggressive chemo and said no more. I was still working and no quite sure how I go through all of that but obliviously I did. I then went onto 3 more doses of chemo and again said no more. I never wanted chemo in the first place and should of stood my ground but I listened to the Dr's as it was routine, well routine is not always right for everyone. Radiotherapy was also dropped to 16 days with 10 shots per visit, so 160 doses.. and yeah the boob is now fried and wont move..although it is getting softer to touch. So from Jan 2017 - Oct 2019 I got on with living. I ended up with Lymphoedema in the left arm,, not good but I have a great network with the Lympho Therapist and sleeves. I was going really well, working, riding my motorbike and just getting on with things. In July 2019 I got a very sore left knee, thinking it was just arthritis I let it go for about 10 weeks. When the pain became so bad I went to a new GP who sent me for ultrasounds.... nothing other than OA. Ok, so lets do a bone scan just to have a look and see. Scan was done on a Monday, results were to be picked up on a Wednesday. We didn't find the answer to the pain in the knee, although there was OA but they did find 5 lesions in my bones. 1 in the skull, L1, L2, L3,L5. no symptoms at all. Ok, so where to from here. A new Oncologist (the last one and I did not Gel). New medications, Immunotherapy meds. Palbociclib 125mg and Arimidex 1mg. Three months later I had another bone scan to see how it was all going. Damn again, another 7 lesions. T11, S1, L4, Hip and Socket joints, and hip area. So all up 12 lesions. They did a biopsy on the S1 and I would not wish that on my worst enemy, it bloody well nearly killed me. The results came back as the same Breast ca as before so this was treatable. During this time in Oct 2019, I became a Nanny to my little man Archie.. I am so in LOVE. Fast forward again to 2021. A few more bone scans every 6 months, blood tests every month for ca markers, 21 days of Palbociclib, and daily for Arimidex. I am now 18 months into this next journey with Stage 4 Metastatic Breast Cancer. I still work as a Clinical Facilitator for Universities looking after RN Students, although I feel tired all the time. I still ride my motorbike, hubby and I brought a Motorhome to start going away,. In 2018 I did a Cert IV in Celebrancy and became a Marriage Celebrant in March 2019 and I am about to go down the pathway of learning how to be a Funeral Planner/Director. I am currently a Funeral Celebrant. This is my business and I love what I do. I am also a Justice of the Peace now. So yes life is somewhat busy.... hahahaha... well totally busy but I love it and it will keep going as long as I can keep going. I am in the process (slowly) of planning my own funeral. It is not morbid, it is reality and I want to go out the way I want. My family will just follow my lead and plans. All going well, I hope to have a pre Funeral party and have all my friends and family there to see me before I kick the bucket, but I am also very much aware of living while I can. www.lovelisallaroundus.com.au This is my website and it means I get to share my love, friendship and hope with everyone.
Effect of High-dose Vitamin C Combined With Anti-cancer Treatment on Breast Cancer Cells.
Please see medical research link below regarding this topic. I haven't been on this site for a while and surprised I couldn't find topics on this subject except a comment from a BCNA staffer. As well as the usual Specialists, I see an integrative GP. She administers high dose Vit C infusions to breast cancer patients, including me. I've been clear now for 8 years. The medical evidence for this being beneficial in the fight against breast cancer cells is becoming clear and more widely accepted now, even among the old guard. So, I am wondering, why don't more women know about this? Are there any other women having it? If so, how is it going? https://www.ncbi.nlm.nih.gov/m/pubmed/30711954/
Gemcitabine and Carboplatin
Hi all, i was was wondering if anyone has had any experience with these drugs and how they handled the side effects. I have metastatic breast cancer which has stopped responding to the present treatment, and this is an option. However, the doctor feels it has only a 10 to 20 percent chance of being effective, so I need to decide whether to do this. I’d appreciate any information. Cheers, Boobless2
Are you using Kisqali?
Hi, I have an opportunity to talk to the manufacturers of the medication Kisqali. If you are using it, I’m wondering if there is anything about this drug that you would like me to pass on them? For example - was the information you received from your oncologist and in writing informative and easy to understand? Have you had any concerns you might have about taking this medication answered? Would it help to have a phone number or an email address in order to talk to a representative from the drug company? What about the side effects? I’d like the tablets to be smaller - a small thing but perhaps useful for others as well? What do you think? Is there anything else I can pass on to them? I’m very happy to hear all your suggestions, ideas and thoughts. Here is a wonderful opportunity for us, as users, to be proactive in getting the company to understand how this drug is effecting us and how they can further support us. I’m looking forward to your comments and suggestions so that I can have a bigger impact on the way the company works with its consumers. Debbie Packham