Giredestrant Reduces Recurrence Risk More Than Tamoxifen, Aromatase Inhibitors - lidERA Trial
Is/was anyone on the 'lidERA' Trial? Apparently there is evidence that Giredestrant may Reduce Recurrence Risk up to 30% More Than Tamoxifen, Aromatase Inhibitors. https://www.breastcancer.org/research-news/giredestrant-reduces-recurrence-risk-better-than-tamoxfen-and-aromatase-inhibitors Giredestrant Reduces Recurrence Risk More Than Tamoxifen, Aromatase Inhibitors Results from the lidERA trial suggest that giredestrant could be a new standard of care for early-stage hormone receptor-positive breast cancer. Written by Jamie DePolo | Reviewed by Kevin Fox, MD Published on December 21, 2025 In this article Taking giredestrant after surgery to remove early-stage hormone receptor-positive HER2-negative breast cancer seems to lower the risk of the cancer coming back (called recurrence) more than taking tamoxifen or an aromatase inhibitor. Giredestrant is a new oral selective estrogen receptor downregulator (SERD), a type of hormonal therapy. The research was presented at the 2025 San Antonio Breast Cancer Symposium. Key takeaways People who took giredestrant were 30% less like to have any type of recurrence — cancer coming back in the breast area or in any part of the body — than people who took tamoxifen or one of the aromatase inhibitors: Arimidex (chemical name: anastrozole), Aromasin (chemical name: exemestane), or Femara (chemical name: letrozole). People who took giredestrant were 31% less likely to have distant or metastatic recurrence — cancer coming back in a part of the body away from the breast — than people who took tamoxifen or an aromatase inhibitor. The side effects of giredestrant were similar to those of tamoxifen and the aromatase inhibitors – hot flashes and joint and muscle pain – but they appeared to be less severe. About 5% of people taking giredestrant stopped treatment because of side effects compared to about 8% of people taking an aromatase inhibitor or tamoxifen. What the results mean for you Longer follow-up of the study is needed, but if the results are confirmed, the findings could mean the first major change in treatment after surgery for early-stage hormone receptor-positive breast cancer in more than 25 years. While giredestrant isn’t yet approved by the U.S. Food and Drug Administration (FDA), Genentech, the company that makes it, is expected to apply for approval very soon. Why do the study? After surgery, many people diagnosed with early-stage hormone receptor-positive HER2-negative breast cancer take hormonal therapy, usually tamoxifen or an aromatase inhibitor, for five to 10 years to lower the risk of recurrence. Although survival rates are high with this treatment, up to 33% of people have the cancer come back. Research also shows that many people struggle with the side effects of tamoxifen and the aromatase inhibitors; studies suggest that up to 50% of people either don’t start their prescribed medicine or stop taking it early. “In early [estrogen receptor]-positive breast cancer, challenges with disease recurrence and treatment adherence mean there is an urgent need for more effective, tolerable endocrine therapies,” Aditya Bardia, MD, MPH, professor of medicine at the David Geffen School of Medicine at UCLA, said during a media briefing on the results. Bardia is also director of translational research integration at the UCLA Health Jonsson Comprehensive Cancer Center. Bardia and his colleagues studied whether giredestrant could be a better option than currently used hormonal therapies. About the study The lidERA study included 4,170 people diagnosed with stage I to stage III hormone receptor-positive HER2-negative node-positive breast cancer. Half the people were older than 54 and half were younger. About 60% were post-menopausal. After surgery, the people were randomly assigned to one of two treatments for five years: 2,084 people took giredestrant 2,086 people took tamoxifen or one of the aromatase inhibitors, whichever their doctor recommended; if people had unacceptable side effects, they could switch to a different aromatase inhibitor Detailed results Three years after completing the five years of treatment, 92.4% of the people who took giredestrant were alive with no recurrence compared to 89.6% of people who took tamoxifen or an aromatase inhibitor. This difference was statistically significant, which means that it was likely due to the difference in treatments and not just because of chance. This benefit was consistent regardless of menopausal status, cancer stage, and whether or not a person had received chemotherapy before surgery. Information on overall survival — how long people live whether or not the cancer comes back — wasn’t ready to be analyzed. But Bardia said there was a trend for better survival with giredestrant. The most common treatment-related side effects in both treatment groups were mild and included joint pain, hot flashes, and headache. Less than 2% of the people in either treatment group had serious side effects, such as high blood pressure and joint pain. Bradycardia, or a slow heart rate, is a known side effect of oral SERDs. About 11% of people who took giredestrant had bradycardia compared to about 3% of people who took tamoxifen or an aromatase inhibitor. But most of these cases were grade 1, caused no symptoms, and didn’t require people to pause or stop treatment. “The frequency of side effects were similar, including the frequency of [joint pain], with giredestrant and the standard of care endocrine therapy,” Bardia said during an episode of The Breastcancer.org Podcast, “but treatment discontinuation because of [joint pain] was lower with giredestrant compared to the standard of care endocrine therapy.” References Bardia A., et al. Giredestrant vs standard-of-care endocrine therapy as adjuvant treatment for patients with estrogen receptor-positive, HER2-negative early breast cancer: Results from the global Phase III lidERA Breast Cancer trial. SABCS 2025, Abstract GS1-10.
Neo-N trial in TNBC
Anyone else in the Neo-N trial for triple negative? I’m one of two participants in my hospital in Brisbane and started my first immunotherapy yesterday. Please get in touch if you are part of the trial or are thinking about it. Would be great to chat to other people as treatment progresses.Newly diagnosed
Hi I’m 44 and have just been diagnosed with triple negative metastic breast cancer. It has spread to my liver. First time cancer and extremely scary. After first finding out it was cancer it took nearly 3 weeks to get oncologist appointment and then had a pet scan. They have referred me for a clinical trial at the PA but everything seems to take so long. Meanwhile I’m scared it’s spreading more. Finally got a phone call yesterday to go in tomorrow to have all this pre screening tests done. Let’s hope I meet the criteria. I’ve been just trying to live life normal and trying to be very positive but is so frustrating.
Participate in research aimed at relieving hot flushes and night sweats
Participate in research aimed at relieving hot flushes and night sweats experienced by women after breast cancer. Researchers across several states in Australia are conducting a study to evaluate a potential new treatment aimed at relieving hot flushes and night sweats in women diagnosed with breast cancer who are taking hormone blocking therapy (either tamoxifen or an aromatase inhibitor). While clinical trials have found hormone blocking therapy can significantly reduce the risk of breast cancer coming back (recurring), many women experience menopausal-like symptoms when taking hormone-blocking therapy. While these side effects are mild for many women or lessen over time, some women experience significant symptoms which can be difficult to cope with. The study will determine whether QUE 122 (a small molecule which was found to lessen hot flushes and night sweats in an earlier study) is effective in reducing night sweats and hot flushes in women affected by breast cancer being treated with hormone blocking therapy. You may be eligible to participate if you are: Aged 18 to 70 years Are taking tamoxifen or an aromatase inhibitor (i.e. anastrozole (Arimidex), letrozole (Femara) or exemestane (Aromasin). Are experiencing 7 or more hot flushes/night sweats each day/evening. Are able to attend 6 study visits at the research site over approximately 9 weeks. This study is taking place at sites in Melbourne, Sydney, Adelaide, Brisbane and Perth. If you are interested in participating or would like further information, please contact the study site closest to you
Trial Drug
Hi All, So was with oncologist on Monday and was offered to go on a free trial for a new drug. Just wondered if anyone knew anything about it. It is called Neratinib. Apparently it has been released in the US. Trial approved but not funded in the UK and same in Australia. It’s for women who are oestrogen + and Her2+ and it’s supposed to lesson my chance of recurrence but only by 5%. You take it for a year apparently and side effects can be pretty rough. Would love to hear if you know anything more about it xxx
PIKNIC clinical trial
I was diagnosed with metastatic breast cancer in 2016. I've tried a few different chemos in that time. The latest was Eribulin. All the scans show the cancer is stable but my tumour markers have been rising. I've tolerated the chemo well up until the last 6 weeks where I have been getting almost daily headaches & numerous migraines. So when I saw my oncologist recently he suggested I take a break from the Eribulin for a month which I agreed to. He also asked me if I wanted to be part of a clinical trial. It is called PIKNIC & being run out of Peter Mac in Melbourne. It is a drug you take orally every day. I saw the clinical trial doctor last Friday to get more information. She said the major side effects of this new drug was diabetes. This really concerns me. Is anyone on this site on this trial or know someone on it? What has been your experience? What are the side effects for you? Thanks
