Member: Jen2019 | BCNA Online Network

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Re: Achy hips
@LBUSH I know what you mean, I have thought of stopping treatment too. But I realise, that my chance of recurrence will be minimal if I stay on it. Gentle stretching helps me too. ohh and when I sleep on my side, I use a pillow in between my legs it helps with my hips.
5 years ago Place Side effects
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Re: 6 months Post DCIS now heart failure at 57
@Louise64, i feel for you and life sometimes throw too many curve balls at us. But, you seem to be full of courage just like your mother. Hang in there and you have the BCNA community rallying behind you. I may not know exactly what you're going through but I sure can lend you an ear if you need one. :)
5 years ago Place Living with breast cancer
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Re: Sydney Meet Up 8th May
@FLClover 😂, actually I saw your earlier messages that is when I replied. Is ok, we all lose the plot sometimes. I still love you ❤️
5 years ago Place General
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Re: Sydney Meet Up 8th May
This is great. 😁I can attend but for probably 1 hour as I have to be in Parramatta at 5.30 for another friends bday. Looking forward to meeting everyone.
5 years ago Place General
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Re: Sydney Meet Up 8th May
NewBoobsPLS Sorry, I don't have Instagram.
5 years ago Place General
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Re: Music: what song you are listening to...invites and answers the question ‘how are you’
The best version of "I don't know how to love him" by Yvonne Elliman. She gave a voice to Mary Magdalene, powerful and evoke such emotions of fear and love rolled into one.The first time I watched the musical (Jesus Christ Superstar) was in grade school and I was so moved by Yvonne's portrayal. https://youtu.be/lS2nX4fuzqc
5 years ago Place Managing stress and anxiety
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Re: Sydney Meet Up 8th May
I am interested too
5 years ago Place General
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Re: Feeling better than expected what now
@FLClover, You're right Mon, we have to be strong, loving and supportive with each other. ❤️ Like how you are very supportive of me. 😍
5 years ago Place Living with breast cancer
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Re: Has anyone tested positive for the RAD gene mutation?
Tasia Another biomedical paper published on 2019 link below for your perusal. Not sure again if this is legit. https://pubmed.ncbi.nlm.nih.gov/31409076/ Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer Abstract An inherited predisposition to breast cancer underlies 5-10% of breast tumors. High-risk BRCA1 and BRCA2 genes result in an 85% lifetime risk of breast cancer and a 20-60% lifetime risk of ovarian cancer. Next-generation sequencing or massive parallel sequencing are now established testing methods that enable screening for many genes that predispose to heterogeneous hereditary cancer syndromes (22 genes are required by the health insurance companies). In addition to BRCA1 and BRCA2, inherited mutations in other genes predispose to breast and/or ovarian cancer. High-risk breast cancer genes include TP53, STK11, CDH1, PTEN, PALB2, and NF1, while moderate-risk (2-4 times increased risk) breast cancer genes include ATM, CHEK2, and NBN. Moderate risk is also suggested for Lynch syndrome, MUTYH, BRIP1, RAD51C, RAD51D, BARD1, FANCA, FANCC, FANCM, BLM, WRN genes. In heterozygotes for other recessive syndromes the risk of developing breast cancer is subject to current research. Low-risk genes are (mostly) irrelevant from a clinical perspective. Other genes that increase the risk of ovarian cancer include the genes for Lynch syndrome, the BRIP1, RAD51C and RAD51D genes. Preventive care should be proposed based on assumed cumulative breast cancer risk (see http: //www.mamo.cz): a risk of >20% for BRCA1/2, TP53, PTEN, STK11, CDH1, PALB2, CHEK2, ATM, and NF1; and a risk of 10-20% for BRIP1, RAD51C, RAD51B, BARD1, FANCA, FANCC, FANCM, NBN, BLM, and WRN. The genetic risk should be assessed by a geneticist and be based on inherited mutations and empirical risk according to family history. Prophylactic mastectomy is considered for high-risk gene carriers but not for moderate-risk gene carriers; however, it may be considered if there is an underlying family history, a risk of parenchyma of the mammary gland, or other risk factors. Ovarian cancer risk increases significantly in carriers of the BRIP1, RAD51C, and RAD51D genes. For prevention of ovarian cancer, prophylactic salpingo-oophorectomy is an important component of preventive care. In ovarian cancer families with no identified risk germline mutation, preventive salpingo-oophorectomy is not routinely recommended but may be considered as the only efficient method of prevention due to the increased empirical risk (4 times) of ovarian cancer in first-degree relatives. Supported by the grant project MH CZ - RVO (MMCI, 00209805), AZV 15-27695A and AZV 16-29959A. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers. Submitted: 17. 5. 2019 Accepted: 31. 5. 2019.
5 years ago Place General discussions
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Re: Has anyone tested positive for the RAD gene mutation?
Tasia I found a paper published online dated Sept 28,2011. It says it is peer reviewed but not sure. RAD51C Germline Mutations in Breast and Ovarian Cancer Cases from High-Risk Families https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025632 Abstract BRCA1 and BRCA2 are the most well-known breast cancer susceptibility genes. Additional genes involved in DNA repair have been identified as predisposing to breast cancer. One such gene, RAD51C, is essential for homologous recombination repair. Several likely pathogenic RAD51C mutations have been identified in BRCA1- and BRCA2-negative breast and ovarian cancer families. We performed complete sequencing of RAD51C in germline DNA of 286 female breast and/or ovarian cancer cases with a family history of breast and ovarian cancers, who had previously tested negative for mutations in BRCA1 and BRCA2. We screened 133 breast cancer cases, 119 ovarian cancer cases, and 34 with both breast and ovarian cancers. Fifteen DNA sequence variants were identified; including four intronic, one 5′ UTR, one promoter, three synonymous, and six non-synonymous variants. None were truncating. The in-silico SIFT and Polyphen programs were used to predict possible pathogenicity of the six non-synonomous variants based on sequence conservation. G153D and T287A were predicted to be likely pathogenic. Two additional variants, A126T and R214C alter amino acids in important domains of the protein such that they could be pathogenic. Two-hybrid screening and immunoblot analyses were performed to assess the functionality of these four non-synonomous variants in yeast. The RAD51C-G153D protein displayed no detectable interaction with either XRCC3 or RAD51B, and RAD51C-R214C displayed significantly decreased interaction with both XRCC3 and RAD51B (p<0.001). Immunoblots of RAD51C-Gal4 activation domain fusion peptides showed protein levels of RAD51C-G153D and RAD51C-R214C that were 50% and 60% of the wild-type, respectively. Based on these data, the RAD51C-G153D variant is likely to be pathogenic, while the RAD51C- R214C variant is hypomorphic of uncertain pathogenicity. These results provide further support that RAD51C is a rare breast and ovarian cancer susceptibility gene.
5 years ago Place General discussions
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Work and breast cancer
PUBLIC GROUP - This is a space to connect around the challenges and questions that come with managing work and breast cancer. Whether you're navigating time off, returning to work, dealing with workplace conversations, or exploring your rights and options, you're welcome here. This group is open to the public (not just members of our online network) to help broaden access to important information, practical advice, and peer support.
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Let's talk: vaginas, menopause & me
PRIVATE GROUP. This group is a safe, supportive space to talk about sexual health and emotional wellbeing during and after breast cancer. We discuss topics like menopause, vaginal dryness, pain during sex, UTIs, and changes in libido, and share ideas and products that may help. Whether you're navigating intimacy with a partner or reconnecting with yourself, you're not alone here. This is a place for open, respectful conversations and shared understanding.
Choosing breast reconstruction
PRIVATE GROUP. Choosing breast reconstruction after single or double mastectomy can feel overwhelming, and deeply personal. This group is here to connect you through others' stories and images. Please respect everyone’s privacy—do not copy or share content outside this space. Information is based on personal experience and is not medical advice; always consult your healthcare team for guidance. ⚠️CONTENT WARNING⚠️ Members may share photos of breast surgeries. These images or discussions may be distressing or triggering for some. If you need support, please contact the BCNA Helpline - we are here for you.

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Jen2019

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Work and breast cancer

Let's talk: vaginas, menopause & me

Choosing breast reconstruction