It works for me but I only put it on the outside when necessary. The vaginal canal is OK now. My atrophy happened when on Arimidex (Arimatose inhibitor) because I am post menopausal - I tried them all and it was ugly!!. My Oncologist put me back on Tamoxifen (only 3 a week at the moment) because vaginal atrophy was causing me great distress. (He said Tamoxifen will fix that - it brings it back - I don't know how but it worked for me). I no longer have Urinary Tract Infections which were constant. He said we are all different with different physiology etc. They just don't know how much is too much or how little is too little. As I said in earlier post: dosage studies have never been done. I just know I can't take one every day at the moment. Good luckxx