Hi Renee73, I have had 4 AC & 10 rounds of Taxol so far. I didn't experience severe bone pain & aches until round 5 & then after that they were mild each time until now. Last night was very uncomfortable with aching all night & today but now all gone & I didn't take anything. I did have acupuncture tonight & that always makes me feel better generally. Also exercising helps. It is so unpredictable but I think normal too. It should only last for 24 to 36 hours. If you are worried you should speak to your oncologist.