I honestly believe it depends where you are in terms of Menopause, I had no trouble with Tamoxifen and I was pre menopause and yes I have trouble on Arimidex but I believe its only because chemo through me into Menopause which has exaggerated alot of the sypmptoms. I certainly find ways to deal with the symptoms and pro active now with my exercise physiologist and its making a ton of difference. I still have 4yrs on Arimidex but can I say something?? this is a recurrence for me in 4yrs, Im not willing to NOT take one of these when I know the stats are really good, particularly for Arimidex...and added bonus I have 2 prolia injections a year for bones which strangely wards of BC as well. Im the first to admit yeah it is tough, Im drug sensitive allergic to narcotics, but really feel these meds are very manageable. :) Melinda xo