Hi @Sue_w I too had very similar side effects to you. I took Tamoxifen for 2 years & nearly had a complete mental health breakdown before I realised it was the cumulative effects of the side effects particularly the lack of quality sleep. Letrozole felt even worse & the side effects from Venlafaxine dreadful.
I now don’t take any hormone blockers, it’s scary because I don’t know how much risk I’m at for the cancer to come back. But I literally feel sick thinking about taking oestrogen blockers again.
Maybe a low dose Tamoxifen would be a more happy medium. I might mention this study to my onc too.
