Yes it's cumulative. I didn't have nausea as much as terrible tummy burns. I did continue with nexium and sometimes needed zantac and the odd stemitil. Make sure you tell about the pains in fingers and toes. I used to get awful leg pain about day 3. I took regular panadol osteo and tramadol when really bad. I got really miserable on taxol as it was weekly so you didnt get the break as you did from AC (the no issues was the intense nausea and constipation issues with AC)
Again maybe try stemitl instead as the restless legs might be the maxalon. It could be from neuroparhic pain though. I didn't get tingling in toes until about dose 8. I was on really high doses of steroids on taxol as I had an allergic reaction to the drug at st dose. Once the steroids were cut back it was all better, that wasn't for some time. I just stayed up watching netflex as I couldn't sleep.
I did get balance issues, tinnitus on it. Soubds awful I know. But a few weeks after I was good and 5 months on its a distant memory. I think I have chemo amnesia.
I struggled with all spicy foids. Veg tasted disgusting and red wine burned my gut...as did fruit. But it recovers.
I like to say really...taxol not better than AC just different. It's all horrid. But it's effective chemo. X