Hi Wendy, sorry to hear you are having such a rough time on the Xeloda. Have you had a few weeks break from the drug. I am not on Xeloda now but I remember when the side effects were bad the oncologist gave me a 4 week break to recover and have a few days away. My tumor markers were never as low as yours. My main problem was my feet. My hands were not too bad just some numbness of the finger tips. Diarrohea at least once a cycle. I have nothing to complain about after hearing about you. It's hard. But just keep putting 1 foot in front of the other and ask your oncologist for some time out. Sending you lots of hugs and remember that Wendy's are strong you can do it .were all in this together. Love Wendy h 67