Thanks for your reply Katie46. I lasted the two years on the 150mg x 2 daily. It was hell, especially on my stomach, but my oncologist wasn't keen on me reducing it. I am so glad to be finished that but now have been told that I will continue with these other side effects as a result of Letrozole. For my condition there is not really any other option so it is going to be a long ride! I was hoping once the Abem was done things would go back to more normality. Appears not! I hope you do not have the side effects I am getting and that you do really well once you are finished your treatment.