I had chemo, double mastectomy, radiation and Herceptin after original diagnoses in 2012. I refused to take Arimidex as I was so sure I had got rid of that cancer forever. Got diagnosed with bone metastases in 2016. I wish, now, I had taken Arimidex. I think it would have helped as my tumour was oestrogen triggered. As said before, doesn't matter if your ovaries don't work anymore, your body will make it in other ways. There are supplements you can take to help with the side effects of the aromotase inhibitor.