I've been told I have an opioid malabsorption condition. Apparently certain enzymes can be absent in the gut which breaks down the chemical components into bits and pieces which are then turned from one chemical to another which the body then absorbs and reacts with pain receptors. The following do zip for me. Morphine, codeine, endone, targin, pethidine. They all have no effect on pain whatsoever, and I just vomit non stop. My body can absorb some artificial opioids if given sub lingually (under the tongue). This is absorbed through the mucous membrane in the mouth, and goes directly into the bloodstream, bypassing the intestines, which don't break it down. Cocaine works the same, absorbed through the mucous membrane in the nose. Also have had Fentanyl patches which worked well. Again absorbed through the skin and directly into the bloodstream. (Think nicotene patches and hormone patches) This method gives a slow, sustained relief, and I was given the same drug under the tongue until the patch had gotten into my system. This was sorted out by the pain clinic at a major teaching hospital in Sydney. What a relief to finally have something on my record, to be used if necessary.