I am in the same boat as you. I was diagnosed a year ago, took 20 mg Tamoxifen for a few months but my osteoarthritis (fingers and feet) worsened consderably. I also suffered from low grade nausea most of the time and as I am also suffering from fibromyalgia, the tightness in my muscles worsened resulting in painful nocturnal calf and quad cramps. I then dropped the dose to 10 mg/day, but the side effects were still so hard to deal with. I am currently on 10 mg every second day and I have got a review with my specialist scheduled on 21/10. The nausea has finally eased and I am enjoying my food again, but I am still struggling with painful joints and at the same time I am scared about a recurrence of the cancer taking a reduced dose. The muscle cramps only occur now and again which is a great relief. My specialist told me right at the start that quality of life is very important. This is such a difficult situation to deal with. I do also get hot flushes but they are not too bad although I think I will struggle more in the warm weather to come.