@Trikki2, hi lovely, I have just finished round 2( TCx4) with a neulasta injection following each chemo, I take one loratadine 10mg (antihistamine )morning of the injection and one a day for next 4days (check with oncologist first, so they can give the ok, this is an individual thing so I had to get permission first), this seemed to help with bone ache, my were minimal and could be handled with a Panadol, otherwise not too bad on the side effects. heartburn is my thing for first couple days after chemo, but I tend to push the fluids and try to keep moving as much as I can. Most of all, day by day is the way I handle it, keeps me from getting overwhelmed, hugs for you xxxxx